| Name |
Time period |
Type / Pre-human host |
Death toll |
| Antonine Plague |
165-180 |
Believed to be either smallpox or measles |
5M |
| Japanese smallpox epidemic |
735-737 |
Variola major virus |
1M |
| Plague of Justinian |
541-542 |
Yersinia pestis bacteria / Rats, fleas |
30-50M |
| Black Death |
1347-1351 |
Yersinia pestis bacteria / Rats, fleas |
200M |
| New World Smallpox Outbreak |
1520 – onwards |
Variola major virus |
56M |
| Great Plague of London |
1665 |
Yersinia pestis bacteria / Rats, fleas |
100,000 |
| Italian plague |
1629-1631 |
Yersinia pestis bacteria / Rats, fleas |
1M |
| Cholera Pandemics 1-6 |
1817-1923 |
V. cholerae bacteria |
1M+ |
| Third Plague |
1885 |
Yersinia pestis bacteria / Rats, fleas |
12M (China and India) |
| Yellow Fever |
Late 1800s |
Virus / Mosquitoes |
100,000-150,000 (U.S.) |
| Russian Flu |
1889-1890 |
Believed to be H2N2 (avian origin) |
1M |
| Spanish Flu |
1918-1919 |
H1N1 virus / Pigs |
40-50M |
| Asian Flu |
1957-1958 |
H2N2 virus |
1.1M |
| Hong Kong Flu |
1968-1970 |
H3N2 virus |
1M |
| HIV/AIDS |
1981-present |
Virus / Chimpanzees |
25-35M |
| Swine Flu |
2009-2010 |
H1N1 virus / Pigs |
200,000 |
| SARS |
2002-2003 |
Coronavirus / Bats, Civets |
770 |
| Ebola |
2014-2016 |
Ebolavirus / Wild animals |
11,000 |
| MERS |
2015-Present |
Coronavirus / Bats, camels |
850 |
| COVID-19 |
2019-Present |
Coronavirus – Unknown (possibly pangolins) |
9,800 (as of Mar 19, 2020) |
Note: Many of the death toll numbers listed in the table above are “guesstimates” based on available research.